Title: LCAM-FEBS  Advanced course“Functional imaging of nuclear organisation & signaling”
Date: 9-15 June 2019
Location: LCAM-FNWI, -NKI & -AMC
Contact: Mark Hink
Previous editions: 2015, 2017 & In the Footsteps of van Leeuwenhoek (bi-annual)
Sponsor:  Federation of European Biochemical Societies (FEBS)

Introduction: 

The ability of cells to perceive and correctly respond to their environment is the basis of development, tissue repair and immunity as well as normal tissue homeostasis.  The nucleus plays a central role in these processes because in this organelle the genetic blueprint of the cell is located and highly dynamic processes like gene activation, transcription and chromosome duplication are taking place. By increasing the understanding of the complex nuclear organisation and signaling, related diseases can be treated more effectively.

Because of the recent technological revolution in advanced light microscopy (i.e. functional imaging of molecules, development of caged compounds and biosensors) it is now possible to directly monitor the dynamics of (single) molecules in living cells. Several new microscopy techniques are ideally suited for studying cellular signals but their application remains limited because most biologists have never been introduced to these technologies. This practical advanced course will be organized to provide students in this field the theoretical background and give hands-on experience of state-of-the-art microscopy techniques.
The practical sessions will cover several microscopy techniques to study molecular complexes in biological systems, such as:

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